Edorium Journal of

Surgery

 
     
Original Article
 
Prophylactic effect of hyperthermic intraperitoneal chemotherapy in patients with high risk of developing peritoneal carcinomatosis from colorectal cancer
Mohamed I. Abdelhamid1, Mohammed M. Alkilany1, Osama abd Elaziz1, Mohamed Abdelgawad2
1Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine, Zagazig University, Zagazig, Egypt

Article ID: 100017S05MA2017
doi:10.5348/S05-2017-17-OA-1

Address correspondence to:
Mohamed Ibrahim Abdelhamid
General and Laparoscopic Surgery Department
Zagazig University, Zagazig
sharkia
Egypt

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How to cite this article
Abdelhamid MI, Alkilany MM, abd Elaziz O, Abdelgawad M. Prophylactic effect of hyperthermic intraperitoneal chemotherapy in patients with high risk of developing peritoneal carcinomatosis from colorectal cancer. Edorium J Surg 2017;4:1–7.


ABSTRACT

Aims: Hyperthermic intrapritoneal chemotherapy (HIPEC) seems to be a promising solution against development of peritoneal carcinomatosis (PC) complicating some cases of colorectal cancer (CRC). The aim of this study was to report the prophylactic effect of HIPEC against PC after radical resection of CRC.
Methods: This prospective randomized comparative study included patients who presented to the Surgery Department of Zagazig University Hospitals with operable CRC with high risk of developing PC during the period from Januarys 2013 and June 2014. These patients were randomly divided into two groups; each one was 25 in number. One group was treated with surgery alone while the other was managed with HIPEC following surgery. Our patients were followed up till December 2016 to detect PC (mean follow-up period was 39 months).
Results: There were statistically significant difference between both groups in which application of HIPEC following radical surgery decreases the incidence of PC recurrence (p = 0.039). On the other hand, postoperative complications demonstrated that cardiorespiratory complications (p = 0.042) and length of hospital stay showed significant higher incidence in the HIPEC group (p= 0.046) whereas other complications as wound complications showed no statistically significant difference between two groups (p = 0.15).
Conclusion: HIPEC has a remarkable prophylactic effect against PC recurrence and should be tried in CRC patients as long as no contraindications for this chemotherapeutic based procedure.



Keywords: Colorectal cancer, Hyperthermic intraperitoneal chemotherapy, Peritoneal carcinomatosis, Prophylactic

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Author Contributions:
Mohamed I. Abdelhamid – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohammed Alkilany – Substantial contributions to conception and design, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Osama Abd Elaziz – Substantial contributions to conception and design, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed Abdelgawad – Substantial contributions to conception and design, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Mohamed I. Abdelhamid et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.





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